Formosa Pharmaceuticals Technology

Technology Advantages|APNT® nanoparticle formulation platform

APNT® is an innovative and breakthrough technology compared with other particle size reduction platforms:

How does APNT® work ?

APNT® does not employ metal or plastic “beads” and therefore avoids contamination derived from fragmentation from bead collision and grinding. APNT® products have high purity, as it utilizes salts or sugars for milling, which can remain as part of the final formulation.

APNT® nanoparticle formulation technology

Beads Milling

Beads Milling and contamination risks

APNT® Technology vs. Other Particle Size Reduction Platforms

Key features APNT® Technology Other Particle Size Reduction Platforms (Beads-Milling, NanoEdge™, Cryomilling)
Aseptic Filtration is possible * Narrow particle size distribution and the particle size of APNT nanolized API can be less than 200nm to pass aseptic filter (0.2 micron).
Tunable particle size & narrow particle size distribution * Difficult in tuning particle size
* NanoEdge™ has broad particle distribution .
Preservation of crystal structure * Cryomilling: amorphization of material from crystal cracking at low temperature
Adequate operational temperature * Beads-Milling generates high temperature which may affect API.
* Cryomilling requires extremely low temperatures.
Free of solvents and harsh additives * Use of organic solvents that may remain in final product and present possible toxicology or allergen risk
* Beads-Milling use of harsh additives that remain in final product
Low contamination risk * Beads-Milling has higher contamination risk from beads.
All excipients are GRAS level * APNT®: All excipients are GRAS (Generally Regarded As Safe)

APNT® Can help your asset by

Scroll to Top